PLEASE NOTE: I will combine shipping please ask

A few months after the first film's events, Professor Roy Curien at the fictional Cuesta Verde University (CVU) in Seattle has managed to subdue and contain a "Hyper sapiens" specimen, who is revealed to be his son, Rudy Curien (a survivor of Isla del Morte incident). Curien experiments on another survivor (Alicia), trying to determine the source of her immortality, with apparent disregard for the rotted state of Alicia's body. When Curien creates a serum that he believes will bring back the dead and grant immortality, Curien murders one of his students and injects her with the serum. She returns to life, infects Curien, and breaks out of the building.

A month later, the university has a full-fledged outbreak, confirmed by AMS reconnaissance teams. Jake Ellis, an agent for AMS, goes in search of fellow agent Alexandra "Nightingale" Morgan. He finds her on a date at a restaurant, where she must execute several infected people before she returns to base with Ellis. After being ordered to retrieve a blood sample from the originally infected specimen on campus, they are warned that missiles will level the campus at midnight, regardless of whether the agents are still present. She assigns a gender-mixed Special Forces team of U.S. Marines to provide them with backup. Ellis openly questions the competence of the soldiers, leading to friction between the two units. Upon arrival at CVU, the soldiers encounter zombies. One soldier panics, and another becomes infected after his gun jams. When the others discover his injury, they sever his infected arm, but he turns and infects the team medic; Ellis executes both. The team continues forward into the university proper.